Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes.
نویسندگان
چکیده
3-Hydroxy-1,2-dimethylpyridin-4(1H)-one (deferiprone) is a successful iron chelator, which has been widely investigated for its activity in mitigating iron overload and in protecting against oxidative stress due to Reactive Oxygen Species (ROS). Herein, we present the synthesis, characterisation, physicochemical properties and antioxidant activity of two novel bioconjugates of β-cyclodextrin bearing the deferiprone moiety either on the upper rim (1) or on the lower rim (2) of the cyclodextrin and their iron(III) complexes. Protonation and iron stability constants were measured by spectrophotometric titration for the two systems and antioxidant activity studied for both the ligands and the iron(III) complexes.
منابع مشابه
Studies on inclusion complexes of 2-[Substituted arylideamino]-1, 3, 4-thiadiazino [6,5b]indole with β- Cyclodextrin
Inclusion complexes of 2-[Arylidenamino]-1,3,4-thiadiazino[6,5b]indoles have been prepared with β-cyclodextrin so as to increase the solubility of these compounds in polar medium which may increase theirbioaccessibility. The formation of inclusion complexes is known from the study of changes in physical andspectral properties of the compounds. The stability of the inclusion complexes has been s...
متن کاملVanadium Complexes with Maltol and Deferiprone Ligands: Synthesis, Characterization and In vitro Antiproliferative Activity toward Different Cancer Cells
In a systematic effort to identify a potent antiproliferative agent, four complexes of vanadium containing maltol and deferiprone ligands were synthesized and evaluated for their cytotoxic activity against five human and animal cancer cell lines, including human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line ...
متن کاملSynthesis of β-cyclodextrin-lysozyme conjugates and their physicochemical and biochemical properties
Recently a great interest in the field of protein engineering and the design of innovative drug delivery systems employing specific ligands such as cyclodextrins is observed. The paper reports the solid state, thermal method for protein coupling with β-cyclodextrin and the physicochemical and biological properties of the obtained conjugates. The structure of the obtained conjugates was investig...
متن کاملEvaluation of antioxidant and anti-cancer properties of curcumin / beta- and gamma-cyclodextrin complexes modified with chitosan nanoparticles on lung cancer cell A549
The aim of this study was to investigate the interaction modification of curcumin complex molecule (CUR) in beta- and gamma-cyclodextrin (β-CD and γ-CD) carriers with chitosan (CS) nanoparticles for targeted drug delivery and to compare their performance. The targeted drug delivery system includes the therapeutic agent of the CS nanoparticles targeting section of the same drug and the CD carrie...
متن کاملNew conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems.
Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transiti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Dalton transactions
دوره 41 10 شماره
صفحات -
تاریخ انتشار 2012